Investigation into conolidine has led to discovery of the opioid receptor in the body called ACKR3/CXCR7. ACKR3 appears to be quite possibly the most wanted focus on for conolidine, which also disregards the opposite 4 classical opioid receptors(3). thank you.. A: There is limited details on contraindications concerning Conolidine https://thesocialdelight.com/story6395696/not-known-details-about-conoldine-alternative-natural-pain-relief