Weak/Intensive Metabolizers, CYP2D6 The formation with the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around 7% of the population has reduced exercise of your CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme procedure. These people today are “bad metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, among other medicines. https://martinanwfn.blogzet.com/facts-about-tramadol-50-mg-online-revealed-50658498