Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts in the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactions, whic... https://torreyz111vog2.loginblogin.com/profile