Schematic representation of activated and inhibited Wnt/β-catenin pathway. “WNT ON point out�? Upon ligation of Wnts for their receptors composed of frizzled proteins and LRP5/six, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates into the nucleus and binds to TCF/LEF transcription variables https://martiny863nsw6.wikifordummies.com/user